Before MMA, Miocic did well in college wrestling and baseball, which contributed to his athletic foundation. He is recognized for his striking and wrestling skills, helping him win the UFC Heavyweight Championship three times and set a record with three consecutive title defenses. His notable victories include defeats of Fabricio Werdum, Alistair Overeem, and Junior dos Santos.
Miocic's most famous rivalry is with Daniel Cormier, facing him in a trilogy that is a highlight of UFC history, winning two of the three bouts.